Endocrine Abstracts

Introduction: It is important to ensure the information shared on social media is up to date to current clinical practice, reliable and appropriate to the target audience. YouTube is the most popular social media platform for video-based medical information worldwide. You and Your Hormones is a UK-based website endorsed by Society for Endocrinology hosting videos on various medical conditions aimed at the public. CoMICs (Concise Medical Information Cines) are short videos prov...

Polycystic ovary syndrome (PCOS) is prevalent metabolic disorder in women, associated with androgen excess and insulin resistance. These two major features are closely correlated, but the direction of causality remains unclear. Aldoketoreductase type 1C3 (AKR1C3) converts the androgen precursor androstenendione to testosterone (T), and is highly expressed in subcutaneous (SC) adipose tissue. We hypothesised that adipose tissue represents an important site linking androgen acti...

IntroductionCoronavirus disease (COVID-19) in people with diabetes is associated with a disproportionately worse prognosis. DKA is an acute complication of diabetes with a mortality rate of approximately 0.67%. Little is known about natural history of DKA in the presence of COVID-19 infection. This study aimed to explore the effects of COVID-19 infection on presentation, clinical course and outcome in patients presenting with DKA.M...

Background: Diabetic ketoacidosis (DKA) is an acute endocrine emergency in people with diabetes. Paucity of information prevails over sex- and age-related variations in patients presenting with DKA.Objective: To assess the impact of age and sex in the clinical course, presentation, outcome and management of DKA in people with type 1 (T1DM) and type 2 diabetes (T2DM).Methods: We included all DKA from April 2014 to September 2020 in ...

Objectives: Limited evidence exists studying the impact of ethnicity on diabetic ketoacidosis (DKA). We aimed to study the impact of ethnicity on presentation, management and outcome of DKA in type 1 (T1DM) and type 2 (T2DM) diabetes.Methods: All DKA episodes from April 2014 to September 2020 in a UK tertiary care centre were identified. Data were collected on diabetes type, demographics, biochemical and clinical features on admission, and DKA management...

Objectives: We explored the differences in severity and outcomes of diabetic ketoacidosis (DKA) in people with type 1 (T1DM) and type 2 diabetes (T2DM).Methods: All DKA episodes from April 2014 to September 2020 at a tertiary care centre in the United Kingdom were identified. People admitted with DKA were classified as having T1DM or T2DM based on previously established diagnosis, autoantibody status, and/or phenotypic features. We compared the differenc...

Background: Diabetic ketoacidosis (DKA) is the most common acute endocrine complication needing hospital admission. Morbidity and mortality resulting from DKA are largely preventable if we can identify and act on gaps in management in relation to current guidelines.Objectives: To establish a common DKA registry to identify gaps in management and share best practices across centres.Methods: All people admitted with DKA at four hospi...

Polycystic Ovary Syndrome (PCOS) is one of the most common endocrine conditions affecting women of reproductive age. Recent studies have shown several long term comorbidities associated with PCOS, thus making it essential that all physicians, regardless of training and specialty, understand and empower women with PCOS to adopt evidence-based behavioral changes. This study set out to establish an understanding of evidence-based lifestyle management of PCOS and the current pract...

Objectives: Pre-clinical medical education is mainly delivered in didactic large-group lectures, where complex new terminology and concepts are introduced. Mounting evidence suggests that pre-class activities introducing new material can increase student performance. Concise Medical Information Cines (CoMICs) compresses information on various diseases into 5-minute videos. This study assessed the effectiveness of CoMICs as a pre-lecture resource to enhance learning and motivat...

Background: Severe hypoglycemia, marked by blood glucose levels below 3 mmol/l (level 2) or necessitating third-party assistance (level 3), poses a significant risk leading to unplanned hospital admissions in individuals with diabetes. However, there is a paucity of information on admitted patients’ characteristics, management, and outcomes.Objective: To explore the characteristics of the population, precipitating factors and outcomes of people admi...